The Transcription Factor HLH-30/TFEB Regulated Autophagy and Modulates Longevity in C. Elegans: QSB seminar

Lecture/Seminar - Natural Sciences | January 24 | 11-11:50 a.m. | Social Sciences and Management Building, Half Dome

Location:  5200 North Lake Rd, Merced, CA 95343

Speaker: Dr. Louis Lapierre, Post Doctoral Associate, Sanford Burnham Medical Research Institute

Sponsor: Quantatative

Louis Lapierre, a postdoctoral associate from Sanford Burnham Medical Research Institute, presents a lecture on HLH-30 as a novel longevity-modulating transcription factor.

Professor Fabian Fillip sponsors the seminar that will examine the cytosolic degradation process of autophagy. It has emerged as a key mechanism required for lifespan extension in C. elegans, yet the underlying regulatory mechanisms remain unclear.

The mammalian transcription factor TFEB was recently found to coordinately up-regulate several genes involved in both the formation of the autophagosome and in lysosomal processing.

In his study, Fillip demonstrates that the nematode transcription factor HLH-30 is a functional homolog of mammalian TFEB and a novel regulator of lifespan in C. elegans. Collectively, the findings indicate that HLH-30 is a novel longevity-modulating transcription factor that displays functional similarity to its mammalian counterpart, TFEB.

Event Contact: Fabian Filipp, Assistant Professor, School of Natural Sciences, ffilipp@ucmerced.edu, 209-228-4509